Anbarasu Kumaraswamy
Education
PhD, Biotechnology, Indian Institute of Technology Madras
MS, Biotechnology, Bharathiar University
BS, Biotechnology, PSG College of Arts and Science
Research Interests
Role of LSD1 in CRPC progression
Study of epigenetic plasticity in CRPC via NGS modalities
Funding
Smith Family Postdoctoral Scholar
Contact
Email: kumarasw@umich.edu
Mentors who have altered my life: My high school biology teacher instilled my interest in biological science and my mentor during my post-graduation introduced me to research by asking curious questions on simple day-to-day life events.
In my time off, I enjoy: Experimenting with spicy dishes, exploring classical Tamil literature and mythology.
What profession, other than your own, would you enjoy? I would enjoy being an archeologist.
Select Publications
Kumaraswamy A, Duan Z, Flores D, Zhang C, Sehrawat A, Hu YM, Swaim OA, Rodansky E, Storck WK, Kuleape JA, Bedi K, Mannan R, Wang XM, Udager A, Ravikumar V, Bankhead A 3rd, Coleman I, Lee JK, Morrissey C, Nelson PS, Chinnaiyan AM, Rao A, Xia Z, Yates JA, & Alumkal JJ. LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. JCI Insight (2023). DOI: 10.1172/jci.insight.167440
Tyner JW, Haderk F, Kumaraswamy A, Baughn LB, Van Ness BG, Liu S, Marathe H, Alumkal JJ, Bivona TG, Chan KS, Druker BJ, Hutson AD, Nelson PS, Sawyers CL, & Willey CD. Understanding Drug Sensitivity and Tackling Resistance in Cancer. Cancer Research (2022). DOI: 10.1158/0008-5472.CAN-21-3695
Kim DH, Sun D, Storck WK, Welker Leng KR, Jenkins C, Coleman DJ, Sampson DA, Guan X, Kumaraswamy A, Rodansky ES, Urrutia JA, Schwartzman J, Zhang C, Beltran H, Labrecque MP, Morrissey C, Lucas JM, Coleman I, Nelson PS, Corey E, Handelman SK, Sexton JZ, Aggarwal R, Abida W, Feng FY, Small EJ, Spratt DE, Bankhead III A, Rao A, Gesner EM, Attwell S, Lakhotia S, Campeau E, Yates JA, Xia Z, & Alumkal JJ. BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program. Clinical Cancer Research (2021). DOI: 10.1158/1078-0432.CCR-20-4968
Kumaraswamy A, Welker Leng KR, Westbrook TC, Yates JA, Zhao SG, Evans CP, Feng FY, Morgan TM, & Alumkal JJ. Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer. European Urology (2021). DOI: 10.1016/j.eururo.2021.03.005
Coleman DJ, Sampson DA, Sehrawat A, Kumaraswamy A, Sun D, Wang Y, Schwartzman J, Urrutia J, Lee AR, Coleman IM, Nelson PS, Dong X, Morrissey C, Corey E, Xia Z, Yates JA, & Alumkal JJ. Alternative splicing of LSD1+8a in neurodendocrine prostate cancer is mediated by SRRM4. Neoplasia (2020). DOI: 10.1016/j.neo.2020.04.002
Kumaraswamy A, Mamidi A, Desai P, Sivagnanam A, Revathi P, Ramakrishnan C, Gromiha M, Rajalingam K, & Mahalingam S. The Non-Enzymatic RAS Effector RASSF7 Inhibits Oncogenic c-Myc Function. Journal of Biological Chemistry (2018). DOI: 10.1074/jbc.RA118.004452