PhD, Biotechnology, Indian Institute of Technology Madras
MS, Biotechnology, Bharathiar University
BS, Biotechnology, PSG College of Arts and Science
Role of LSD1 in CRPC progression
Study of epigenetic plasticity in CRPC via NGS modalities
Teacher who has altered my life: My high school biology teacher instilled my interest in biological science and my mentor during my post-graduation introduced me to research by asking curious questions on simple day-to-day life events.
In my time off, I enjoy: Experimenting with spicy dishes, exploring classical Tamil literature and mythology.
What profession, other than your own, would you enjoy? I would enjoy being an archeologist.
Kim DH, Sun D, Storck WK, Welker Leng KR, Jenkins C, Coleman DJ, Sampson DA, Guan X, Kumaraswamy A, Rodansky ES, Urrutia JA, Schwartzman J, Zhang C, Beltran H, Labrecque MP, Morrissey C, Lucas JM, Coleman I, Nelson PS, Corey E, Handelman SK, Sexton JZ, Aggarwal R, Abida W, Feng FY, Small EJ, Spratt DE, Bankhead III A, Rao A, Gesner EM, Attwell S, Lakhotia S, Campeau E, Yates JA, Xia Z, & Alumkal JJ. BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program. Clinical Cancer Research (2021). DOI: 10.1158/1078-0432.CCR-20-4968
Kumaraswamy A, Welker Leng KR, Westbrook TC, Yates JA, Zhao SG, Evans CP, Feng FY, Morgan TM, & Alumkal JJ. Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer. European Urology (2021). DOI: 10.1016/j.eururo.2021.03.005
Coleman DJ, Sampson DA, Sehrawat A, Kumaraswamy A, Sun D, Wang Y, Schwartzman J, Urrutia J, Lee AR, Coleman IM, Nelson PS, Dong X, Morrissey C, Corey E, Xia Z, Yates JA, & Alumkal JJ. Alternative splicing of LSD1+8a in neurodendocrine prostate cancer is mediated by SRRM4. Neoplasia (2020). DOI: 10.1016/j.neo.2020.04.002
Kumaraswamy A, Mamidi A, Desai P, Sivagnanam A, Revathi P, Ramakrishnan C, Gromiha M, Rajalingam K, & Mahalingam S. The Non-Enzymatic RAS Effector RASSF7 Inhibits Oncogenic c-Myc Function. Journal of Biological Chemistry (2018). DOI: 10.1074/jbc.RA118.004452
Ananthi S, Lakshmi CNP, Atmika P, Kumaraswamy A, & Mahalingam S. Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma. Scientific Reports (2018). DOI: 10.1038/s41598-018-19937-3
Kowshik J, Mishra R, Sophia J, Rautray S, Kumaraswamy A, Reddy GD, Dixit M, Mahalingam S, & Nagini S. Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model. Scientific Reports (2017). DOI: 10.1038/s41598-017-01960-5
Thoompumkal IJ, Rehna K, Kumaraswamy A, & Mahalingam S. Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation. Cell Cycle (2016). DOI: 10.1080/15384101.2016.1242534
Datta D, Kumaraswamy A, Rajabather S, Priya RS, Desai P, & Mahalingam S. Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1. Journal of Biological Chemistry (2015). DOI: 10.1074/jbc.M115.637280