PhD, Pathology and Pathophysiology, Central South University, China
BS, Biotechnology, Hunan Normal University, China
Epigenetic reprogramming in prostate cancer therapy resistance
Mentors who have altered my life: My PhD advisor, Dr. Ya Cao, stimulated my enthusiasm for biomedical research, leading me to the scientific world of cancer. My postdoc supervisor, Dr. Matthew D. Scharff, who trained me comprehensively about B cell / Antibody Immunology, taught me how to use the most advanced technologies to do science rigorously.
In my time off, I enjoy: Cooking and baking, traveling with families and friends.
What profession, other than your own, would you enjoy? I would like to have my own bookstore with a dessert house.
Kumaraswamy A, Duan Z, Flores D, Zhang C, Sehrawat A, Hu YM, Swaim OA, Rodansky E, Storck WK, Kuleape JA, Bedi K, Mannan R, Wang XM, Udager A, Ravikumar V, Bankhead A 3rd, Coleman I, Lee JK, Morrissey C, Nelson PS, Chinnaiyan AM, Rao A, Xia Z, Yates JA, & Alumkal JJ. LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. JCI Insight (2023). DOI: 10.1172/jci.insight.167440
Storck WK, May AM, Westbrook TC, Duan Z, Morrissey C, Yates JA, & Alumkal JJ. The Role of Epigenetic Change in Therapy-Induced Neuroendocrine Prostate Cancer Lineage Plasticity. Frontiers in Endocrinology (2022). DOI: 10.3389/fendo.2022.926585
Duan Z, Baughn LB, Wang X, Zhang Y, Gupta V, MacCarthy T, Scharff MD, & Yu G. Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes. Proc Natl Acad Sci U S A (2021). DOI: 10.1073/pnas.2104013118
Yu G, Wu Y, Duan Z, Tang C, Xing H, Scharff MD, & MacCarthy T. A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes. PLOS Computational Biology (2021). DOI: 10.1371/journal.pcbi.1009323
Wang X, Duan Z, Yu G, Fan M, & Scharff MD. Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells. mBio (2018). DOI: 10.1128/mBio.02315-17
Duan Z, Zheng H, Liu H, Li M, Tang M, Weng X, Yi W, Bode AM, & Cao Y. AID expression increased by TNF-alpha is associated with class switch recombination of Ig alpha gene in cancers. Cell Mol Immunol (2016). DOI: 10.1038/cmi.2015.26
Duan Z, Zheng H, Xu S, Jiang Y, Liu H, Li M, Hu D, Li W, Bode AM, Dong Z, & Cao Y. Activation of the Ig Ialpha1 promoter by the transcription factor Ets-1 triggers Ig Ialpha1-Calpha1 germline transcription in epithelial cancer cells. Cell Mol Immunol (2014). DOI: 10.1038/cmi.2013.52