PhD, Chemical Biology, University of Michigan
BS, Biochemistry, Arizona State University
Transcriptional reprogramming in neuroendicrine prostate cancer
Metabolic plasticity of metastatic prostate cancer
Teacher and mentors who have altered my life: My high school biology teacher, Mr. Raymond Pfriem, showed me how much I could love biochemistry with his enthusiasm for science. My graduate school advisor, Dr. Daniel Bochar, taught me more than I could ever have expected and cemented my love for academic science.
In my time off, I enjoy: Playing baseball and ice hockey, exploring Michigan, and spending time outdoors.
What profession, other than your own, would you enjoy? Long haul trucking, owner-operator of a landscaping company, or a mechanical or structural engineer.
Kumaraswamy A, Duan Z, Flores D, Zhang C, Sehrawat A, Hu YM, Swaim OA, Rodansky E, Storck WK, Kuleape JA, Bedi K, Mannan R, Wang XM, Udager A, Ravikumar V, Bankhead A 3rd, Coleman I, Lee JK, Morrissey C, Nelson PS, Chinnaiyan AM, Rao A, Xia Z, Yates JA, & Alumkal JJ. LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. JCI Insight (2023). DOI: 10.1172/jci.insight.167440
Westbrook TC, Guan X, Rodansky E, Flores D, Liu CJ, Udager AM, Patel RA, Haffner MC, Hu YM, Sun D, Beer TM, Foye A, Aggarwal R, Quigley DA, Youngren JF, Ryan CJ, Gleave M, Wang Y, Huang J, Coleman I, Morrissey C, Nelson PS, Evans CP, Lara P, Reiter RE, Witte O, Rettig M, Wong CK, Weinstein AS, Uzunangelov V, Stuart JM, Thomas GV, Feng FY, Small EJ, Yates JA, Xia Z, & Alumkal JJ. Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity. Nature Communications (2022). DOI: 10.1038/s41467-022-32701-6
Kim DH, Sun D, Storck WK, Welker Leng KR, Jenkins C, Coleman DJ, Sampson DA, Guan X, Kumaraswamy A, Rodansky ES, Urrutia JA, Schwartzman J, Zhang C, Beltran H, Labrecque MP, Morrissey C, Lucas JM, Coleman I, Nelson PS, Corey E, Handelman SK, Sexton JZ, Aggarwal R, Abida W, Feng FY, Small EJ, Spratt DE, Bankhead III A, Rao A, Gesner EM, Attwell S, Lakhotia S, Campeau E, Yates JA, Xia Z, & Alumkal JJ. BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program. Clinical Cancer Research (2021). DOI: 10.1158/1078-0432.CCR-20-4968
Coleman DJ, Sampson DA, Sehrawat A, Kumaraswamy A, Sun D, Wang Y, Schwartzman J, Urrutia J, Lee AR, Coleman IM, Nelson PS, Dong X, Morrissey C, Corey E, Xia Z, Yates JA, & Alumkal JJ. Alternative splicing of LSD1+8a in neurodendocrine prostate cancer is mediated by SRRM4. Neoplasia (2020). DOI: 10.1016/j.neo.2020.04.002
Little AC, Kovalenko I, Goo LE, Hong HS, Kerk SA, Yates JA, Purohit V, Lombard DB, Merajver SD, & Lyssiotis CA. High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions. Communications Biology (2020). DOI: 10.1038/s42003-020-0988-z
Little AC, Pathanjeli P, Wu ZF, Bao LW, Goo LE, Yates JA, Oliver CR, Soellner MB, & Merajver SD. IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation Of Synergistic VEGF/CCL-18 Signaling. Frontiers in Oncology (2019). DOI: 10.3389/fonc.2019.00456
Oliver CR, Altemus MA, Westerhof TM, Cheriyan H, Cheng X, Dziubinski M, Wu Z, Yates JA, Morikawa A, Heth J, Castro MG, Leung BM, Takayama S, & Merajver SD. A platform for artificial intelligence bases identification of the extravasation potential of cancer cells into the brain metastatic niche. Lab on a Chip (2019). DOI: 10.1039/c8lc01387j
Wynn ML, Yates JA, Evans CR, Van Wassenhove L, Wu ZF, Bridges S, Bao L, Fournier C, Ashrafzadeh S, Merrins MJ, Satin LS, Schnell S, Burant CF, Merajver SD. RhoC is a Potent Regulator of Glutamine Metabolism and N-acetylaspartate Production in Inflammatory Breast Cancer Cells. Journal of Biological Chemistry (2016). DOI: 10.1074/jbc.M115.703959