Joshua Kuleape
Education
PhD, Medical Biochemistry, Tokyo Medical and Dental University
MPhil, Molecular Cell Biology of Infectious Diseases, University of Ghana
BS, Biochemistry, University of Ghana
Research Interests
Role of RB1 & p53 loss in NEPC progression
Study of epigenetic lineage plasticity
Contact
Email: jkuleape@umich.edu
Teachers and mentors who have altered my life: Lecturers at the Biochemistry Department at University of Ghana were very instrumental in my decision to be a research scientist. My parents modelled hard work and sacrifice; it is true, hard work pays off.
In my time off, I enjoy: Spending time with my wife and son.
What profession, other than your own, would you enjoy? I would probably have loved to be a farmer.
Recent Publications
Kumaraswamy A, Duan Z, Flores D, Zhang C, Sehrawat A, Hu YM, Swaim OA, Rodansky E, Storck WK, Kuleape JA, Bedi K, Mannan R, Wang XM, Udager A, Ravikumar V, Bankhead A 3rd, Coleman I, Lee JK, Morrissey C, Nelson PS, Chinnaiyan AM, Rao A, Xia Z, Yates JA, & Alumkal JJ. LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. JCI Insight (2023). DOI: 10.1172/jci.insight.167440
Sinclear, CK, Maruyama, J, Nagashima, S, Arimoto-Matsuzaki, K, Kuleape, JA, Iwasa, H, Nishina, H, & Hata, Y. Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling. Cancer Science (2022). DOI: 10.1111/cas.15285
Kuleape JA, Hossain S, Sinclear CK, Shimizu T, Iwasa H, Maruyama J, Arimoto-Matsuzaki K, Nishina H, & Hata Y. DNA damage triggers the nuclear accumulation of RASSF6 tumor suppressor protein via CDK9 and BAF53 to regulate p53-target gene transcription. Mol Cell Biol (2021) DOI: 10.1128/MCB.00310-21.
Quaye O, Kuleape JA, Bonney EY, Puplampu P, & Tagoe EA. Imbalance of antioxidant enzymes activities and trace elements levels in Ghanaian HIV-infected patients. PLoS ONE (2019). DOI: 10.1371/journal.pone.0220181
Tagoe EA, Tagoe IN, Kuleape JA, Puplampu P, Amanquah S, Asare‐Anane H, & Quaye, O. Haptoglobin phenotypes with weak antioxidant capacity increase risk factors of cardiovascular disease in Ghanaian HIV‐infected patients on highly active antiretroviral therapy. Tropical Medicine and International Health (2019). DOI: 10.1111/tmi.13229
Kuleape JA, Tagoe EA, Puplampu P, Bonney EY, & Quaye O. Homozygous deletion of both GSTM1 and GSTT1 genes is associated with higher CD4+T cell counts in Ghanaian HIV patients. PLoS ONE (2018). DOI: 10.1371/journal.pone.0195954